Ghosh, Prithwish; Kwon, Na Yeon; Kim, Saegun; Han, Sangil; Lee, Suk Hun; An, Won; Mishra, Neeraj Kumar; Han, Soo Bong; Kim, In Su published an article in 2021. The article was titled 《C-H Methylation of Iminoamido Heterocycles with Sulfur Ylides》, and you may find the article in Angewandte Chemie, International Edition.Synthetic Route of C3H9IOS The information in the text is summarized as follows:
The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochems., functional materials, and other chem. entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogs is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism. Thus, e.g., treatment of pyrazinone I with trimethylsulfoxonium iodide and KOH in H2O afforded II (91%). In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)
Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Synthetic Route of C3H9IOS
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com