The author of 《Carboxylate-Assisted Oxidative Addition to Aminoalkyl PdII Complexes: C(sp3)-H Arylation of Alkylamines by Distinct PdII/PdIV Pathway》 were Whitehurst, William G.; Blackwell, J. Henry; Hermann, Gary N.; Gaunt, Matthew J.. And the article was published in Angewandte Chemie, International Edition in 2019. Name: 2-Iodobenzoic acid The author mentioned the following in the article:
Reported is the discovery of an approach to functionalize secondary alkylamines using 2-halobenzoic acids as aryl-transfer reagents. These reagents promote an unusually mild carboxylate-assisted oxidative addition to alkylamine-derived palladacycles. In the presence of AgI salts, a decarboxylative C(sp3)-C(sp2) bond reductive elimination leads to γ-aryl secondary alkylamines and renders the carboxylate motif a traceless directing group. Stoichiometric mechanistic studies were effectively translated to a Pd-catalyzed γ-C(sp3)-H arylation process for secondary alkylamines. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Name: 2-Iodobenzoic acid Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com