These common heterocyclic compound, 689291-89-2, name is 5-Bromo-2-iodobenzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 689291-89-2
To an oven-dried flask protected under a N2 atmosphere were charged compound 12 (540 mg, 1.74 mmol), trimethylsilylacetylene (0.68 g, 6.9 mmol), PdCl2(PPh3)2 (60 mg, 0.085 mmol), CuI (30 mg, 0.16 mmol), and Et3N (10 mL). The solution was bubbled by N2 at rt for 5 min and then heated to 60 C under stirring and N2 protection overnight. After the reaction was complete as checked by TLC analysis, the solvent was removed by rotary evaporation. The resulting residue was diluted with CHCl3. The mixture was filtered through a MgSO4 pad. The solution obtained was sequentially washed with HCl (aq. 10%) and brine. The organic layer was dried over MgSO4 and concentrated under vacuum to give crude 20, which was further purified by silica flash column chromatography (hexanes/CH2Cl2, 4:1) to yield compound 20 (518 mg, 1.74 mmol, 100%) as a colorless oil.
The synthetic route of 5-Bromo-2-iodobenzaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhou, Ningzhang; Wang, Li; Thompson, David W.; Zhao, Yuming; Tetrahedron; vol. 67; 1; (2011); p. 125 – 143;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com