Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C5H4IN.
Li, Rui;Yang, Chen-Xi;Niu, Bai-Hua;Li, Li-Juan;Ma, Ji-Mei;Li, Zi-Long;Jiang, Hong;Cheng, Wan-Min research published 《 Visible light-induced Ni-catalyzed C-heteroatom cross-coupling of aryl halides via LMCT with DBU to access a Ni(I)/Ni(III) cycle》, the research content is summarized as follows. Highly efficient photoinduced Ni-catalyzed method for the C-heteroatom cross-coupling of aryl halides was reported. The reaction proceeded smoothly in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under visible light irradiation and was distinct from that mediated by photoredox/nickel dual catalysis, requiring no external photosensitizers. A diverse range of nucleophiles, including amines, amides, sulfonamides, carboxylic acids, alcs., thiophenol, phosphite and sodium sulfinate, were successfully coupled with electronically diverse aryl halides, presenting a universal approach for different C-heteroatom coupling reactions. Mechanistic studies suggested that a catalytically active Ni(I) species was generated via photoinduced ligand-to-metal charge transfer (LMCT) with DBU to access a Ni(I)/Ni(III) catalytic cycle.
Formula: C5H4IN, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com