Alfaro, Javier Antonio team published research on Nature Methods in 2021 | 144-48-9

Name: 2-Iodoacetamide, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Name: 2-Iodoacetamide.

Alfaro, Javier Antonio;Bohlander, Peggy;Dai, Mingjie;Filius, Mike;Howard, Cecil J.;van Kooten, Xander F.;Ohayon, Shilo;Pomorski, Adam;Schmid, Sonja;Aksimentiev, Aleksei;Anslyn, Eric V.;Bedran, Georges;Cao, Chan;Chinappi, Mauro;Coyaud, Etienne;Dekker, Cees;Dittmar, Gunnar;Drachman, Nicholas;Eelkema, Rienk;Goodlett, David;Hentz, Sebastien;Kalathiya, Umesh;Kelleher, Neil L.;Kelly, Ryan T.;Kelman, Zvi;Kim, Sung Hyun;Kuster, Bernhard;Rodriguez-Larrea, David;Lindsay, Stuart;Maglia, Giovanni;Marcotte, Edward M.;Marino, John P.;Masselon, Christophe;Mayer, Michael;Samaras, Patroklos;Sarthak, Kumar;Sepiashvili, Lusia;Stein, Derek;Wanunu, Meni;Wilhelm, Mathias;Yin, Peng;Meller, Amit;Joo, Chirlmin research published 《 The emerging landscape of single-molecule protein sequencing technologies》, the research content is summarized as follows. Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-mol. protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biol. discovery and open new avenues for ultrasensitive disease diagnostics.

Name: 2-Iodoacetamide, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com