Application of 88-67-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 88-67-5 as follows.
Prepared according to literature procedure. A solution of 2-iodobenzoic acid (1,240 mg, 5.0 mmol) in Conc. H2SO4 ( 10.00 mL) was heated at 60 C for 20 minutes. The solution was yellow orange. Then N-bromosuccinimide (1,668 mg, 6.0 mmol) was added in three portions each during 15 minutes. The mixture was brown and allowed to stir for 2 hours. After the reaction was completed, filtered and wash with cold water. A white solid was obtain. The aqueous eluted was extracted with EtOAc, the organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated that to obtain white solid. 1H NMR (300 MHz, CDCl3) delta 8.12 (d, J = 2.4 Hz, 1H), 7.90 (d, J = 8.4 Hz, 1H), 7.33 (dd, J = 8.4, 2.4 Hz, 1H); 13C NMR (75 MHz, CDCl3) delta 169.7, 143.2, 136.6, 134.9, 134.7, 122.4, 92.7. Other data was identical to the literature values.
According to the analysis of related databases, 88-67-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Duangjan, Chanikan; Rukachaisirikul, Vatcharin; Saithong, Saowanit; Kaeobamrung, Juthanat; Tetrahedron Letters; vol. 59; 39; (2018); p. 3537 – 3540;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com