Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Tetrahedron: Asymmetry called Solid state properties and effective resolution procedure for guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol, Author is Bredikhina, Zemfira A.; Novikova, Victorina G.; Zakharychev, Dmitry V.; Bredikhin, Alexander A., the main research direction is guaifenesin enantiomer resolution.Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.
Racemic expectorant guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol (2) undergoes spontaneous resolution upon crystallization This fact is confirmed by thermal anal. (single eutectic V-shape binary melting phase diagram, adequate entropy and free energy characteristics). Racemic 2 could be effectively resolved into (S)- and (R)-2 by a preferential crystallization procedure. Single enantiomer drugs levomoprolol and levotensin were obtained by starting from enantiomeric 2 through the sulfite route.
After consulting a lot of data, we found that this compound(60827-45-4)Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com