Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4553-62-2, is researched, SMILESS is N#CC(C)CCC#N, Molecular C6H8N2Journal, Applied Microbiology and Biotechnology called A gram-negative bacterium producing a heat-stable nitrilase highly active on aliphatic dinitriles, Author is Gavagan, J. E.; DiCosimo, R.; Eisenberg, A.; Fager, S. K.; Folsom, P. W.; Hann, E. C.; Schneider, K. J.; Fallon, R. D., the main research direction is gram neg bacteria heat stable nitrilase; Acidovorax heat stable nitrilase; aliphatic dinitrile heat stable nitrilase Acidovorax.HPLC of Formula: 4553-62-2.
A Gram-neg. bacterial strain, identified as Acidovorax facilis strain 72W, has been isolated from soil by enrichment using 2-ethylsuccinonitrile as the sole nitrogen source. This strain grows on a variety of aliphatic mono- and dinitriles. Experiments using various heating regimes indicate that nitrile hydratase, amidase and nitrilase activities are present. The nitrilase is efficient at hydrolyzing aliphatic dinitriles to cyanoacid intermediates. It has a strong bias for C3-C6 dinitriles over mononitriles of the same chain length. Whole, resting cell hydrolysis of 2-methylglutaronitrile results in 4-cyanopentanoic acid and 2-methylglutaric acid as the major products. Heating, at least 20 min at 50°C, eliminates nitrile hydratase and amidase activities, resulting in greater than 97% selectivity to 4-cyanopentanoic acid. The nitrilase activity has good heat stability, showing a half-life of 22.7 h at 50°C and a temperature optimum of at least 65°C for activity. The strain has been deposited as ATCC 55746.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com