COA of Formula: C3H7ClO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Novel S1P1 Receptor Agonists – Part 1: From Pyrazoles to Thiophenes. Author is Bolli, Martin H.; Muller, Claus; Mathys, Boris; Abele, Stefan; Birker, Magdalena; Bravo, Roberto; Bur, Daniel; Hess, Patrick; Kohl, Christopher; Lehmann, David; Nayler, Oliver; Rey, Markus; Meyer, Solange; Scherz, Michael; Schmidt, Gunther; Steiner, Beat; Treiber, Alexander; Velker, Jorg; Weller, Thomas.
From a high-throughput screening campaign aiming at the identification of novel S1P1 receptor agonists, the pyrazole (E)-3-Phenyl-1-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)prop-2-en-1-one emerged as a hit structure. Medicinal chem. efforts focused not only on improving the potency of the compound but in particular also on resolving its inherent instability issue. This led to the discovery of novel bicyclo3.1.0|-hexane fused thiophene derivatives Compounds with high affinity and selectivity for S1P1 efficiently reducing the blood lymphocyte count in the rat were identified. For instance, 3-{2-Ethyl-6-methyl-4-[5-((1aS,5aR)-1,1,2-trimethyl1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)[1,2,4]oxadiazol-3-yl]-phenyl}-propionic acid showed EC50 values of 7 and 2880 nM on S1P1 and S1P3, resp., had favorable pharmacokinetic properties in rat and dog, distributed well into brain tissue, and efficiently and dose dependently reduced the blood lymphocyte count in the rat. After oral administration to spontaneously hypertensive rats, the S1P1 selective 3-{2-Ethyl-6-methyl-4-[5-((1aS,5aR)-1,1,2-trimethyl1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)[1,2,4]oxadiazol-3-yl]-phenyl}-propionic acid showed no effect on mean arterial blood pressure and affected the heart rate during the wake phase of the animals only.
Compounds in my other articles are similar to this one((2S)-(+)-3-Chloropropane-1,2-diol)COA of Formula: C3H7ClO2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com