Synthetic Route of C3H7ClO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Enhancing the detection sensitivity of trace analysis of pharmaceutical genotoxic impurities by chemical derivatization and coordination ion spray-mass spectrometry. Author is Bai, Lin; Sun, Mingjiang; An, Jianguo; Liu, David Q.; Chen, Ted K.; Kord, Alireza S..
Many pharmaceutical genotoxic impurities are neutral mols. Trace level anal. of these neutral analytes is hampered by their poor ionization efficiency in mass spectrometry (MS). Two anal. approaches including chem. derivatization and coordination ion spray-MS were developed to enhance neutral analyte detection sensitivity. The chem. derivatization approach converts analytes into highly ionizable or permanently charged derivatives, which become readily detectable by MS. The coordination ion spray-MS method, on the other hand, improves ionization by forming neutral-ion adducts with metal ions such as Na+, K+, or NH4 + which are introduced into the electrospray ionization source. Both approaches have been proven to be able to enhance the detection sensitivity of neutral pharmaceuticals dramatically. This article demonstrates the successful applications of the two approaches in the anal. of four pharmaceutical genotoxic impurities identified in a single drug development program, of which two are non-volatile alkyl chlorides and the other two are epoxides.
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