Category: iodides-buliding-blocks. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about The effect of the isomers of α-chlorohydrin and racemic β-chlorolactate on the rat kidney. Author is Porter, K. E.; Jones, A. R..
The (R)- [57090-45-6] and (S)-isomers [60827-45-4] of the male antifertility agent α-chlorohydrin have been synthesized. When administered to rats, the (R)-isomer induced a period of diuresis and glucosuria, whereas the (S)-isomer, which possesses the antifertility activity, had no detrimental action on the kidney. Neither of the isomers of α-chlorohydrin nor those of an active analog, 3-amino-1-chloropropan-2-ol, had any inhibitory activity on the oxidative metabolism of glucose [50-99-7] or lactate [50-21-5] in isolated kidney tubules. However, (RS)-β-chlorolactate [1713-85-5], a metabolite common to both compounds, inhibited the oxidation of glucose, lactate, pyruvate [127-17-3], and glutamate [56-86-0] to CO2. It is proposed that the antifertility action of the (S)-isomers of α-chlorohydrin and 3-amino-1-chloropropan-2-ol is unrelated to the renal toxicity of the (R)-isomers, a toxic action involving the inhibition of oxidative metabolism by (S)-β-chlorolactate or a further product of this metabolite.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com