34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C12H9IO
(1): To 1-iodo-2-phenoxybenzene (2 g, 6.8 mmol)a solution of triethylamine (20 mL) added to phenylacetylene(0.83 g, 8.1 mmol), Pd(PPh3)2Cl2 (95 mg, 135 mumol), CuI (26 mg, 135 mumol).Under argon protection conditions, after 10 hours of reaction,Triethylamine was removed under reduced pressure.The residue was extracted with ethyl acetate (20 mL¡Á3).Then washed twice with water (10 mL) and saturated brine (10 mL).Dry over anhydrous sodium sulfate, filter, and remove the solvent under pressure.The residue was purified by silica gel column chromatography eluting elut1-phenoxy-2-(phenylethynyl)benzene(1.6 g, 88% yield).
The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhongshan University Tumor Cure Center (Zhongshan University Affiliated Tumor Hospital ? Zhongshan University Tumor Institute); Wen Shijun; Huang Peng; Zhu Daqian; Tu Yalin; Luo Bingling; (28 pag.)CN108976248; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com