Reference of 14452-30-3,Some common heterocyclic compound, 14452-30-3, name is 1-(3-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Aryl halide (1a,b18a,b, 1.1 equiv, typically ca. 50 mg), NN-AuSIMes (1.0equiv) and a Pd catalyst [Pd(PPh3)4 (10 mol% in most cases), orPd2(dba)3¡éCHCl3 (5 mol% in most cases)] were dissolved ina dry solvent (typically THF) under nitrogen. The mixture washeated at THF reflux temperature (66 C) until the starting Aucomplexwas consumed (monitored by TLC, usually 3h forArI but longer time for ArBr). After the reaction mixture wasconcentrated under reduced pressure, toluene (ca. 3 mL) wasadded to the residue. The filtrate was concentrated. The residuewas separated and purified by chromatography, to afford thecross-coupling product.
The synthetic route of 14452-30-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yamada, Kiyomi; Zhang, Xun; Tanimoto, Ryu; Suzuki, Shuichi; Kozaki, Masatoshi; Tanaka, Rika; Okada, Keiji; Bulletin of the Chemical Society of Japan; vol. 91; 7; (2018); p. 1150 – 1157;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com