In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling, published in 2019, which mentions a compound: 2058236-52-3, mainly applied to alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods, Category: iodides-buliding-blocks.
An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.
I hope my short article helps more people learn about this compound((S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole)Category: iodides-buliding-blocks. Apart from the compound(2058236-52-3), you can read my other articles to know other related compounds.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com