The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole( cas:2058236-52-3 ) is researched.Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole.Lu, Peng; Ji, Chong-Lei; Lu, Zhan published the article 《Nickel-Catalyzed C-H Heteroarylation of Chiral Oxazolines》 about this compound( cas:2058236-52-3 ) in Asian Journal of Organic Chemistry. Keywords: oxazoline chiral preparation; halide heteroaryl oxazoline heteroarylation nickel catalyst. Let’s learn more about this compound (cas:2058236-52-3).
A nickel-catalyzed C-H heteroarylation at the 2-position of oxazolines e.g., (3aR,8aS)-3a,8a-Dihydro-8H-indeno[1,2-d]oxazole with heteroaryl halides such as 2-bromothiophene, 1-bromoisoquinoline, (E)-(2-bromovinyl)benzene, 2,6-dibromopyridine, etc. was developed. Various oxazoline-containing multidentate chiral ligands e.g., (3aR,8aS)-2-(thiophen-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole have been efficiently synthesized.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com