In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7IO3
General procedure: To a solution of the alcohol (1 equiv) in dried THF at 0 C under a nitrogen atmosphere was added the acid (1.5 equiv) and triphenylphosphine (1.7 equiv), respectively. Then diisopropyl azodicarboxylate (1.7 equiv) was added slowly. The reaction mixture was stirred overnight, quenched with saturated NaHCO3, concentrated, and extracted with ethyl acetate for three times. The combined organic phase was dried over Na2SO4, concentrated, and the residue was purified with column chromatography to give the substrate in 60-85% yield.
The synthetic route of 68507-19-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xing, Xiangyou; Zhao, Yaohong; Xu, Chen; Zhao, Xinyang; Wang, David Zhigang; Tetrahedron; vol. 68; 36; (2012); p. 7288 – 7294;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com