Extracurricular laboratory: Synthetic route of 60827-45-4

There is still a lot of research devoted to this compound(SMILES:OC[C@H](O)CCl)COA of Formula: C3H7ClO2, and with the development of science, more effects of this compound(60827-45-4) can be discovered.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Activities of various 6-chloro-6-deoxysugars and (S)α-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro, published in 1982-05-31, which mentions a compound: 60827-45-4, mainly applied to contraceptive male chlorodeoxy sugar; chlorohydrin male contraceptive; toxicity male contraceptive chlorodeoxysugar, COA of Formula: C3H7ClO2.

6-chloro-6-deoxyglucose (I) [40656-44-8], 6-chloro-6-deoxymannose  [4990-81-2], 6-chloro-6-deoxyfructose  [66451-66-9], 6-chloro-6-deoxyglucitol  [76986-26-0], 6-chloro-6-deoxygalactose  [18465-32-2], and (S)α-chlorohydrin  [60827-45-4] all produced spermatoceles in the efferent ducts and epididymis of the rat and were neurotoxic in the mouse, but only α-chlorohydrin caused substantial inhibition of D-glucose  [50-99-7] metabolism in bull spermatozoa in vitro. The relative potencies of the compounds in producing spermatoceles reflected their activities as reversible antifertility agents in the rat but compared to the others 6-chloro-6-deoxymannose was considerably less neurotoxic to mice than might have been anticipated from its contraceptive dose. Thus, different metabolites may be responsible for causing the antifertility and the neurotoxic effects.

There is still a lot of research devoted to this compound(SMILES:OC[C@H](O)CCl)COA of Formula: C3H7ClO2, and with the development of science, more effects of this compound(60827-45-4) can be discovered.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com