Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Article, Research Support, Non-U.S. Gov’t, Experientia called Formation of the active antifertility metabolite of (S)-α-chlorohydrin in boar sperm, Author is Jones, A. R.; Stevenson, D., the main research direction is chlorohydrin metabolism sperm; glycerol chlorohydrin metabolism sperm; enzyme chlorohydrin metabolism sperm.Computed Properties of C3H7ClO2.
Incubation of boar sperm with (S)-α-chlorohydrin (I) [60827-45-4] resulted in formation of (S)-3-chlorolactaldehyde (II) [86747-03-7]. I inhibited the production of 14CO2 when 14C-labeled fructose [57-48-7] was the substrate but had no effect when 14C-labeled glycerol [56-81-5] was used. (R,S)-3-Chlorolactaldehyde [84709-24-0], however, inhibited CO2 formation from glycerol. The oxidation of 14C-labeled glycerol-3-phosphate [57-03-4] was similarly inhibited by I confirming that the presence of glycerol but not its metabolites prevented the oxidation of I to II. Glycerol reversed the inhibition of fructose metab by I. Addnl., preincubation of sperm with I inhibited glycerol metabolism Apparently, I is metabolized to II in sperm by an enzyme involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards I thereby preventing formation of II, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase [9001-50-7].
Here is a brief introduction to this compound(60827-45-4)Computed Properties of C3H7ClO2, if you want to know about other compounds related to this compound(60827-45-4), you can read my other articles.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com