Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Product Details of 5876-51-7
The 248 mg (1mmol) 4 – bromophenylacetic methyl ether, 186 mg (2mmol) aniline, 9.5 mg (0.05mmol) CuI, 10.8 mg (0.05mmol) ligand L2, 424mg (4mmol) potassium phosphate, 1 ml ethanol,, adding 10 ml reaction tube, sealing, 25 C reaction under the condition 12h. After the stop of the reaction, water, extracted with ethyl acetate, washing, saturated salt water washing, after drying with anhydrous sodium sulfate, filtered, the filtrate is distilled under reduced pressure, purification by silica gel chromatography separation column column, shall be 3, 4 – methylenedioxy phenylaniline 192 mg, yield 90%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sun Yat-sen University; Wan Yiqian; Ding Xiaomei; Huang Manna; Zhu Xinhai; Yi Zhou; CN106883132; (2017); A;,
Iodide – Wikipedia,
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