Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 610-97-9, name is Methyl 2-iodobenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C8H7IO2
30 g (114 mmol) methyl 2-iodobenzoate, N, N-dimethylformamide in 1 L round bottom flaskAfter adding 360ml, trimethylsilylacetylene 22.5g (229mmol), 114.9 ml (801 mmol) triethylamineNitrogen was bubbled for 20 minutes by addition of 8 g (11 mmol) of dichloro (bistriphenylphosphine) palladium (II),I put 2.2 g (11 mmol) of Cooper (I) iodideHeat stirred at 80 C. for 3 h.When the reaction was terminated, the reaction solution was purified by a column to obtain 23 g (yield: 86%) of the compound represented by [Formula 191-d].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SFC Ltd.; Park Seok-bae; Lee Se-jin; Kim Jeong-su; (92 pag.)KR101996647; (2019); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com