Synthetic Route of 811842-30-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows.
Preparation 13 2-(3-Bromo-4-fluorophenyl)-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane To a mixture of 2-bromo-1-fluoro-4-iodobenzene (5.0 g, 16.62 mmo) in dioxane (75 mL) was added bis(pinacolato)diboron (4.2 g, 16.62 mmol) and potassium carbonate (3.3 g, 33.2 mmol). The mixture was degassed and recharged with nitrogen. Bis(triphenylphosphine)palladium(ll)dichloride (0.60 g, 0.83 mmol) was added and the mixture heated to 100C for 18 hours under a nitrogen atmosphere. The mixture was diluted with ethyl acetate (300 mL) and washed with saturated ammonium chloride solution, water and brine (200 mL each). The organic layer was evaporated to give the title compound as dark red oil (6.1 g) which was used without further purification. 1 H NMR (400 MHz, CDCI3): delta ppm 1 .33 (s, 12H), 7.10 (t, 1 H), 7.72-7.65 (m, 1 H), 8.00 (dd, 1 H) ppm.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1-fluoro-4-iodobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER LIMITED; OWEN, Robert Mckenzie; PRYDE, David Cameron; TAKEUCHI, Mifune; WATSON, Christine Anne Louise; WO2015/189744; (2015); A1;,
Iodide – Wikipedia,
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