Some common heterocyclic compound, 450412-29-0, name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 450412-29-0
1-bromo-3-fluoro-2-iodobenzene (75 g, 249.3 mmol), and (5-chloro-2-methoxyphenyl)boronic acid (51.1 g, 249.3 mmol) were dissolved in 550 mL of tetrahydrofuran. A 2 M sodium carbonate (Na2CO3) solution (350 mL) and tetrakis(triphenylphosphine)palladium(0) (2.88 g, 2.49 mmol) were added thereto and refluxed for 11 hours. After the reaction was completed, the reaction mixture was cooled to room temperature. The aqueous layer was separated and removed, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting mixture was recrystallized using chloroform and ethanol to obtain Compound A-1 (63.2 g, yield 80%; MS:[M+H]+=314).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 450412-29-0, its application will become more common.
Reference:
Patent; LG CHEM , LTD.; LEE, Jung Ha; LEE, Dong Hoon; PARK, Tae Yoon; CHO, Seong Mi; HEO, Dong Uk; JUNG, Min Woo; (333 pag.)US2020/10476; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com