S-21 News Discovery of 19094-56-5

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19094-56-5.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H4ClIO2

Example 494r-Chloro-3f-[[(2-tricyclo[3.3.1.13’7]dec-l-ylethyl)ammo]carbonyl]-[l,l’-biphenyl]-2-carboxylic acid0 Cla) 2-Chloro-5-iodo-benzoic acid, 1,1-dimethylethyl esterN,N-Dimethylformamide (1 drop) and oxalyl chloride (4.8 mL) were added to a stirredsolution of 2-chloro-5-iodobenzoic acid (5 g) in dichloromethane (20 mL) at 0 C. Thereaction was allowed to warm to room temperature, stirred under nitrogen for 2 hours, andthen evaporated to dryness. The residue was dissolved in tetrahydrofuran (20 mL) andcooled to 0 C. Potassium tert-butoxide (22 mL, 1 M solution in tetrahydrofuran) wasadded over 10 minutes. The reaction was allowed to warm to room temperature and stirredunder nitrogen for 2 hours then poured into saturated aqueous sodium bicarbonate (50 mL).The layers were separated and the aqueous was extracted with diethyl ether (50 mL). Thecombined organics were dried, filtered and evaporated to afford the sub-title compound asan oil (5.7 g).JH NMR (400 MHz, d6-DMSO) 5 7.99 (1H, d), 7.87 (1H, dd), 7.34 (1H, d), 1.54 (9H, s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19094-56-5.

Reference:
Patent; ASTRAZENECA AB; WO2006/25783; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com