627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C3H7IO
The reaction of phenoxazine (500 mg, 2.729 mmol) and NaH (60% dispersion in mineral oil, 136.8 mg, 4.094 mmol) in distilled DMF (10 mL) with 3-bromo-1-propanol (621 mg, 4.094 mmol) ), as described above, gave compound 14 (480.7 mg, 1.992 mmol, 73 %) as dark navy oil.: Rf = 0.33 (n-hexane/EtOAc = 1:1); IR (neat, cm-1) 3365, 3065, 2947, 1592, 1487, 1380, 1272, 1130, 1044; 1H NMR (400 MHz, CD3OD) delta 6.72~6.76 (m, 2H), 6.51~6.61 (m, 6H), 3.66 (t, 2H, J = 5.6 Hz), 3.60 (t, 2H, J = 7.6 Hz), 1.80 (m, 2H); 13C NMR (100 MHz, CD3OD) delta 145.0, 133.4, 123.7, 120.6, 115.0, 111.6, 59.2, 40.5, 27.7; MS (FAB) m/z 241.1 (M+).
The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gim, Hyo Jin; Li, Hua; Lee, Eun; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry Letters; vol. 23; 2; (2013); p. 513 – 517;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com