Related Products of 33348-34-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33348-34-4 as follows.
A solution of the product of Step A (0.32 g, 1 .31 mmol) and 1 M NaN(SiMe3)2 in THF (2.62 ml) in anhydrous THF (2 ml) was stirred at ~-5C for 30 min under N2. To it acetyl chloride (0.1 1 ml, 1 .44 mmol) was and the mixture was stirred overnight at room temperature, than evaporated to dryness under reduced pressure. The residue was diluted to 50 ml with EtOAc, washed with H20, brine, dried over anhydrous MgS04, filtered and the filtrate evaporated to dryness. The residue was purified by crystallization from MeOH to give the title compound (0.26 g, 70%), as colourless solid. 1 H NMR (CDCI3) 8.46 (d, 1 H, J = 9 Hz), 8.03 (s, 1 H), 7.58 – 7.63 (m, 2H), 2.27 (s, 3H).
According to the analysis of related databases, 33348-34-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AKAAL PHARMA PTY LTD; GROBELNY, Damian W; GILL, Gurmit S; WO2014/63199; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com