Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 2401-21-0
EXAMPLE 45 A solution of 5-aminospiro[benzo[b]furan-2(3H),1′-cyclopropane]-3-one (0.181 g.) and pyridine (0.083 mg.) in tetrahydrofuran (5 ml.) was cooled to -17° C. To the solution was added dropwise iodobenzenedichloride (0.282 g.), which had been prepared by conventional method, dissolved in tetrahydrofuran (1.5 ml.) over 50 minutes, followed by stirring for 1 hour. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was washed with water, dried and the solvent was evaporated off. The residue was subjected to column-chromatography, using chloroform as the eluent. The first fraction was concentrated under reduced pressure to remove the solvent. By the above procedure, there was obtained 5-amino-4-chlorospiro[benzo[b]furan-2(3H),1′-cyclopropane]-3-one as yellow crystals. Yield 0.038 g. Mass spectrum: C12 H12 O2 NCl, molecular ion peak (209).
The synthetic route of 2401-21-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US4284644; (1981); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com