Electric Literature of 181765-86-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In an argon atmosphere, 31 methyl 5-bromo-2-iodobenzoate (2.50 g, 7.33 mmol) and 32 tetrakis(triphenylphosphine)palladium (423 mg, 5 mol %) were dissolved in 30 mL of 33 tetrahydrofuran (THF). At ambient temperature 34 2-thienylzinc bromide (1.67 g, 7.33 mmol) was added dropwise, the solution was vigorously stirred and heated to 70 C. overnight. The reaction was stopped with a 2M solution of 35 HCl and the organic phase extracted with diethylether, washed with water and brine, dried over sodium sulfate (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by silica gel chromatography eluting with n-hexane/dichloromethane (DCM): 9:1 (v/v) then 7:3 (v/v), whereby a colourless 36 oil was obtained (2.15 g, 7.24 mmol, 98.7%). (0105) 1H NMR (CDCl3, 200 MHz): delta=7.86 (dd, 1H, 1=4.8 Hz, 1=0.3 Hz, Har), 7.61 (dd, 1H, J=2.1 Hz, 1=8.3 Hz, Har), 7.35 (m, 2H, Har), 7.04 (m, 2H, Har), 3.75 (s, 3H). (0106) 13C NMR (CDCl3, 50 MHz): delta=167.3; 141.1; 134.2; 134.1; 133.3; 133.0; 132.5; 127.7; 127.1; 136.6; 121.9; 62.1; 14.3.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-2-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES; Demadrille, Renaud; Kervella, Yann; Joly, Damien; Godfroy, Maxime; US2019/144677; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com