Electric Literature of 34683-73-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34683-73-3 name is 1-Chloro-6-iodohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 1-chloro-6-iodohexane (5.0 g, 20.24 mmol), 10 mL of acetone, and potassium thioacetate (2.31 g, 20.24 mmol) was stirred at room temperature for 20 h under nitrogen atmosphere. The excess of acetone was removed and the crude product was diluted with water and extracted three times with CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated to give 7a (3.74 g, 95% yield) as a white solid. 1H NMR (500 MHz, CDCl3): delta = 3.46 (t, J = 6.6 Hz, 2H), 2.80 (t, J = 7.4 Hz, 2H), 2.25 (s, 3H), 1.70 (m, 2H), 1,52 (m, 2H), 1.40-1.30 ppm (m, 4H); 13C NMR (125 MHz, CDCl3): delta = 195.8, 44.9, 32.4, 30.6, 29.3, 28.9, 28.0, 26.3 ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-6-iodohexane, and friends who are interested can also refer to it.
Reference:
Article; Banerjee, Sumela; Voit, Brigitte; Heinrich, Gert; Boehme, Frank; Tetrahedron Letters; vol. 53; 17; (2012); p. 2236 – 2238;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com