Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, A new synthetic method of this compound is introduced below., Computed Properties of C14H18I3N3O6
In a three-necked flask equipped with a stirrer and a reflux condenser,5-amino-N, N’-bis- (2,3-dihydroxypropyl) -2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol)N, N-dimethylacetamide (172 ml)Stir,Heated to 50 C dissolved, cooled to 10 C,A solution of chloroacetyl chloride (62 ml, 88.09 g, 0.78 mol)About 30min drop finished,The temperature was raised to 50 C for 3 h,Cooling to 0 ~ 10 ,At 10 ,Dropping 10 ml / L of sodium hydroxide solution 156 ml,Stir at room temperature for 1 h.After adding 100 ml of water, 59 ml of 1N hydrochloric acid was added dropwise, and the mixture was allowed to stand overnight. The filtrate was washed with water and dried to give 83.2 g of a yield of 90.0%.
The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiang Su Heng Rui Medicine Co., Ltd.; Hou, Xianshan; Wang, Junyan; Wang, Zhian; Zhong, Xinguang; (9 pag.)CN106278929; (2017); A;,
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