Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108078-14-4, name is 2-Iodo-3-methylbenzoic acid, A new synthetic method of this compound is introduced below., Computed Properties of C8H7IO2
2-iodo-3-methylbenzoic acid (595mg, 2.27mmol) was dissolved in DCM/MeOH=1/1 (5m1) at 000, then TMS-CH2N2 (2M in Et20, 1 .4m1, 2.8mmol) was added. After 1,5 hours at RT solvents were evaporated. Yield 630mg yellow oil.1HNMR (CDCI3) 5 ppm = = 7.42 – 7.32 (m, 2 H), 7.32 – 7.25 (m, 1 H, under the solvent peak), 2.55 (s, 3 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ROTTAPHARM SPA; STASI, Luigi Piero; ROVATI, Lucio Claudio; ARTUSI, Roberto; COLACE, Fabrizio; MANDELLI, Stefano; PERUGINI, Lorenzo; WO2013/92893; (2013); A1;,
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