6213-88-3, name is (E)-Methyl 3-iodoacrylate, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of (E)-Methyl 3-iodoacrylate
Step C: To a solution of methyl (E)-methyl 3-iodoacrylate (372 g, 1.75 mol, 1.00 equiv) in dichloromethane (3600 mL) was added dropwise diisobutylaluminum hydride (2296 g, 2.30 equiv, 25%) with stirring at 0C. The resulting solution was stirred for 3 h at room temperature, then quenched by the addition of 1000 mL of aq. NH4C1 (1M). The organic layer was washedwith 1 x 800 mL of HC1 (1M) and 1 x 800 mL of brine, dried over anhydrous sodium sulfate, filtered, concentrated under vacuum. The resulting residue was applied onto a silica gel colunm and eluted with ethyl acetate/petroleum ether (1:10) to afford (E)-3 -iodoprop-2-en- 1 -ol.
The synthetic route of 6213-88-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHOBANIAN, Harry; DEMONG, Duane; GUO, Yan; HU, Zhiyong; MILLER, Michael; PIO, Barbara; PLUMMER, Christopher, W.; XIAO, Dong; YANG, Cangming; ZHANG, Rui; WO2015/119899; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com