Related Products of 3930-83-4,Some common heterocyclic compound, 3930-83-4, name is 2-Iodobenzamide, molecular formula is C7H6INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At room temperature,A reaction tube equipped with a stirring magnet was charged with 0.2 mmol of the compound represented by the formula (I-2)0.005 mmol catalyst Dichloro (p-cymene) ruthenium dimer ([RuCl2 (cymene)] 2),0.24 mmol cesium acetate,Then purged with nitrogen,Under nitrogen protection was added 1mL isopropanol,Stirring heated to 100 ,And reacted at this temperature for 20h.After the reaction,The reaction solution was cooled to room temperature,Filtration with a layer of silica gel funnel,Then, the solvent was distilled off under reduced pressure,The residue was purified by flash column chromatography (petroleum ether / ethyl acetate,Both volume ratio of 1: 1) purification,Thus, the target dehalogenation product represented by formula (III-2) was obtained.Calculated,The yield is 98%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodobenzamide, its application will become more common.
Reference:
Patent; Wenzhou University; Xia Yuanzhi; You Tingjie; (11 pag.)CN106588687; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com