Adding a certain compound to certain chemical reactions, such as: 116632-39-4, name is 5-Bromo-2-iodotoluene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 116632-39-4, HPLC of Formula: C7H6BrI
sec-BuLi (1.4M in cyclohexane, 137.4 ml, 192.4mmol) was added dropwise to a suspension of (2,8-dibenzothiophenediyl)bis-9H,9’H-carbazole (82.5 g, 160.3 mmol)in tetrahydrofuran (1650 ml) at -74 C. After stirring at -40C. for 4 hours, the reaction mixture was re-cooled to -74 o C.and isopropoxyboronic acid, pinacol ester ( 45.8 ml, 224.4mmol) was added dropwise and the mixture allowed towarm to room temperature over night. It was then cooled to-30 C., quenched by the dropwise addition of HCl (2M indiethylether, 88.2 ml, 176.3 mmol), warmed to ambienttemperature and concentrated under reduced pressure. Theresulting precipitate was removed and the filtrate concentratedunder reduced pressure and recrystallized (once fromhexane:toluene and twice from acetonitrile:toluene) to give(A) as a white solid (49.6 g, 48% yield) after drying at 50C. under vacuumHPLC: 95.88%.[0126] 1H-NMR (600 MHz, CDC13 ):delta H [ppm] 1.47 (s,12H), 7.28 (m, 4H), 7.40 (m, 8H), 7.70 (dd, 1=1.9 Hz, 8.5Hz, lH), 8.15 (m, 6H), 8.29 (d, 1=1.7 Hz, lH), 8.38 (d, 1=2.0Hz, lH).
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Reference:
Patent; Cambridge Display Technology Limited; Sumitomo Chemical Company Limited; Steudel, Annette; Bourcet, Florence; (29 pag.)US2018/342684; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com