In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 364-77-2 as follows. Quality Control of 2-Iodo-5-fluoronitrobenzene
Into a round bottom flask was added 3-ethynyl-2-fluoropyridine (0.3 g, 0.002 mol), 4- fluoro-l-iodo-2-nitrobenzene (0.675 g, 0.00253 mol), bis(triphenylphosphine)palladium(II) chloride (0.09 g, 0.1 mmol), copper(I) iodide (0.04 g, 0.2 mmol), and triethylamine (0.52 mL, 3.7 mmol) in N,N-dimethylformamide (4 mL). The reaction was stirred at room temperature for 2 hours. The reaction was extracted with ethyl acetate, and the combined organic extracts were washed with brine (3x), dried over MgSO4, and purified by column chromatography on silica gel (10% ethyl acetate 90% hexanes), to give 0.443 g of product. 1H nuMR (400 MHz, CDCl3): delta 8.44-8.50 (m, IH), 7.99-8.02 (m, IH), 7.79-7.90 (m, IH), 7.78-7.82 (m, IH), 7.37- 7.42 (m, IH), 7.23-7.29 (m, IH). MS [M+H]=261.0.
According to the analysis of related databases, 364-77-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INCYTE CORPORATION; WO2007/38215; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com