Adding a certain compound to certain chemical reactions, such as: 450412-28-9, name is 1-Bromo-3-chloro-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 450412-28-9, Recommanded Product: 1-Bromo-3-chloro-2-iodobenzene
Step 1: 1-bromo-3-chloro-2-cyclopropylbenzene The mixture of 1-bromo-3-chloro-2-iodobenzene (7 g, 22.1 mmol), cyclopropylboronic acid (3.8 g, 44.2 mmol), Pd (dppf) Cl 2 (1.6 g, 2.21 mmol) and K 2CO 3 (2 g, 7.3 mmol, 1.0 eq) in dioxane (100 mL) was heated at 70 C for 12 hours under N 2 protection. TLC showed the reaction was complete and a new spot formed. The mixture was cooled to room temperature and was diluted with EtOAc (150 mL) and H 2O (50 mL). The organic phase was separated and washed with water (150 mL), brine (150 mL), dried over Na 2SO 4, and concentrated. The residue was purified by column chromatography on silica gel (eluent: PE) to give 1-bromo-3-chloro-2-cyclopropylbenzene (3 g, crude), which was used directly in next step.
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Reference:
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com