Application of 83863-33-6,Some common heterocyclic compound, 83863-33-6, name is 5-Iodo-2-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-iodo-2-methyl-phenylamine (0.5 g, 1.62 mmol) (Aldrich) in toluene (5 mL) were added 2-(tri-n-butylstannyl-oxazole (0.5 mL, 2.43 mmol) (Aldrich) and tetrakis-(triphenyl-phosphine)palladium(0) (0.018 g, 0.01 mmol) (Strem Chemicals). The reaction mixture was heated at 100 C. for 14 hours. The reaction mixture was cooled down and the solvent was evaporated. The crude material was then purified by column chromatography. The desired product was eluted with 40% EtOAc. The desired fractions were evaporated to afford 2-methyl-5-oxazol-2-yl-phenylamine. (Yield 0.03 g, 11%). HR-MS (ES+) m/z Calculated for C10H11N2O ([M+H]+): 175.0866. Found: 175.0865.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Iodo-2-methylaniline, its application will become more common.
Reference:
Patent; Dominique, Romyr; Luk, Kin-Chun; Qiao, Qi; Rossman, Pamela Loreen; US2012/184548; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com