In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34270-90-1 as follows. Quality Control of 1-Iodo-2-(2-iodoethoxy)ethane
A mixture of compound 1 (1 mmol), 1-iodo-2-(2-iodoethoxy)ethane (1 mmol) and anhydrouspotassium carbonate (140 mg, 1 mmol) in anhydrous acetonitrile (10 mL) was heated under reflux for1 h and then quenched with water (5 mL). Product 47 was extracted with ethyl acetate and purified ona chromatotron eluting with dichloromethane/methanol (8:2).Yield 66%; m.p. >200 C (decomp.); 1H-NMR (DMSO-d6): delta 8.55 (m, 1H), 8.46 (d, J = 5.2 Hz, 1H), 7.83(m, 1H), 7.10 (m, 2H), 4.13 (m, 4H), 3.98 (m, 4H), 3.74 (m, 4H), 3.67 (m, 4H). HR-MS (ESI). Calcd forC16H21N4O2 (M+): m/z 301.1665. Found: m/z 301.1650. Anal. Calcd for C16H21N4IO2: C, 44.87; H, 4.94;N, 13.08. Found: C, 44.97; H, 5.09; N, 12.69.
According to the analysis of related databases, 34270-90-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Strekowski, Lucjan; Saczewski, Jaros?aw; Raux, Elizabeth A.; Fernando, Nilmi T.; Klenc, Jeff; Paranjpe, Shirish; Raszkiewicz, Aldona; Blake, Ava L.; Ehalt, Adam J.; Barnes, Samuel; Baranowski, Timothy C.; Sullivan, Shannon M.; Sata?a, Grzegorz; Bojarski, Andrzej J.; Molecules; vol. 21; 4; (2016);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com