Adding a certain compound to certain chemical reactions, such as: 689291-89-2, name is 5-Bromo-2-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 689291-89-2, COA of Formula: C7H4BrIO
(Z)-l,2-bis(5-bromo-2-iodophenyl)ethene (18a). A solution of phosphonium salt 16a (3.84 g, 6.02 mmol) in THF (60 mL) was cooled to 0 C in a 250 mL Schlenk flask under nitrogen with stirring. Potassium ‘butoxide (815 mg, 7.12 mmol) was added portionwise and the resulting mixture was held at 0 C for 30 min. A solution of benzaldehyde 17a (1.7 g, 5.5 mmol) in THF (60 mL) was added dropwise at 0 C and the reaction was allowed to warm up to room temperature and left stirring for 24 h. The reaction mix was partitioned between 1 : 1 water: diethyl ether. The aqueous layer was removed and extracted with diethyl ether (3x) and the organics were dried with MgS04, filtered and the solvent removed under reduced pressure to provide an off white solid that was further purified by a short plug (Si02: 10% ethyl acetate in hexane) to yield 2.95 g (4.99 mmol, 91%) 82:18 Z:E of 18a as an off-white solid that was used without further purification. -NMR (400 MHz, CDC13) delta: 7.70 (d, 2H, J= 8.4 Hz), 7.05 (dd, 2H, J= 8.4, 2.4 Hz), 7.02 (d, 2H, J= 2.4 Hz), 6.58 (s, 2H); HRMS (FAB) m/z calculated for Ci4H8Br2l2 Pv ]; 587.7082, found 587.7067.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-iodobenzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE JOHNS HOPKINS UNIVERSITY; TOVAR, John Dayton; CARUSO, Jr., Anthony; WO2011/127383; (2011); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com