Reference of 33348-34-4, A common heterocyclic compound, 33348-34-4, name is 4-Amino-3-iodobenzonitrile, molecular formula is C7H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Description for D20; delta-Cyano-IH-indole^-carboxylic acid (D20); A suspension of 4-amino-3-iodobenzonitrile (2.44 g), 2-oxopropanoic acid (2.64 g), DABCO (3.36 g), and Pd(OAc)2 in DMF (30 ml.) was heated to 105 0C and stirred at that temperature for 1 hour. The solvent was evaporated. EtOAc (200 ml.) was added and the resulting solution was washed with water (100 ml.) and aqueous NaOH solution (20 ml_). The combined aqueous solution was extracted with EtOAc (3 x 150 ml_). The organic fractions were combined. The combined solution was dried over anhydrous magnesium sulfate. The dried solution was concentrated. The residue was triturated to afford 5-cyano-1 /-/-indole-2-carboxylic acid (D20) (1.1 g) as a brown solid.
The synthetic route of 33348-34-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/153307; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com