Electric Literature of 31599-61-8,Some common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
0.288 mol of 3,4-dimethyl iodobenzene, 0.24 mol of carbazole, 0.02 mol of phenanthroline, 0.02 mol of cuprous iodide,Cesium carbonate 0.384 mol was charged into a 1000 ml three-necked flask, dissolved in 300 ml of DMF,Vacuum – nitrogen three times, the temperature to 152 C, the reaction overnight. The reaction solution was passed through a silica funnel,Rinse with methylene chloride to no product dissolution;Spin to about 400ml with 500ml water, liquid, take dichloromethane phase, washed with water three times; spin dry,Add 100ml dissolved,Add 500ml of ethanol to a large amount of solid precipitation, filtration, vacuum drying at 55 .To give 0.2136 mol of 9- (3,4-dimethylbenzene) -9H-carbazole in 89% yield
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1,2-dimethylbenzene, its application will become more common.
Reference:
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Gao, Chunji; Wang, Yongguang; Li, Wenjun; Bi, Yan; (17 pag.)CN104650044; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com