Adding a certain compound to certain chemical reactions, such as: 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20555-91-3, Formula: C6H3Cl2I
General procedure: A mixture of an appropriate unnatural amino acid carboxamide 6 (0.15-0.2 mmol, 1 equiv), an appropriate aryl iodide (5 equiv), Pd(OAc)2 (10 mol%) and AgOAc (2.5 equiv) in anhydrous toluene (2-3 mL) was heated at 110 C for 15-24 h under a nitrogen atm or in a sealed tube. After the reaction period, the reaction mixture was concentrated under reduced pressure to afford a crude reaction mixture, which was purified by column chromatography on neutral alumina or silica gel (eluent EtOAc:hexane) to give the corresponding arylated amino acid (see the respective Schemes/Tables for the specific entries). 3.4.5. 3-(3,4-Dichlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)butanamide (8f). The compound 8f was obtained after purification by column chromatography on silica gel (EtOAc:hexane 40:60) as a colourlesssolid (65 mg, 65%); Rf (40% EtOAc/hexane) 0.6; mp:186e188 C; IR (DCM): 3055, 2985, 1711, 1265, 746 cm1; 1H NMR(400 MHz, CDCl3): dH 9.70 (1H, br. s), 8.81 (1H, dd, J1 4.2,J2 1.6 Hz), 8.47 (1H, dd, J1 7.5, J2 1.0 Hz), 8.14 (1H, dd, J1 8.3,J2 1.5 Hz), 7.70 (2H, dd, J1 5.4, J2 3.1 Hz), 7.60 (2H, dd, J1 5.5,J2 3.0 Hz), 7.53 (1H, d, J 2.0 Hz), 7.48e7.44 (2H, m), 7.41e7.36(2H, m), 7.28e7.26 (1H, m), 4.03e3.95 (3H, m), 3.03e2.90 (2H, m);13C NMR (CDCl3, 101 MHz): dC 168.4, 168.2, 148.2, 141.1, 138.1, 136.2,134.0,133.9,132.8, 131.7,131.3,130.7,129.8,127.8,127.3,127.2, 123.3,121.6, 121.5, 116.3, 42.8, 41.8, 40.3; HRMS (ESI) calcd forC27H20Cl2N3O3 [MH] 504.0882 found 504.0901.
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Reference:
Article; Tomar, Radha; Bhattacharya, Debabrata; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 75; 17; (2019); p. 2447 – 2465;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com