Reference of 4387-36-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4387-36-4, name is 2-Iodobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
A modified literature procedure was employed. ADDIN EN.CITE Finnegan1958951959517Finnegan, William G.Henry, Ronald A.Lofquist, RobertAn Improved Synthesis of 5-Substituted TetrazolesJournal of the American Chemical SocietyJournal of the American Chemical SocietyJ. Am. Chem. Soc.J Am Chem Soc3908-3911801519581958/08/01American Chemical Society0002-7863https://doi.org/10.1021/ja01548a02810.1021/ja01548a0281In a 500 mL round bottom flask equipped with magnetic stir bar, 2-iodobenzonitrile (10.0 g, 0.0436 mol), NH4Cl (4.67 g, 0.0872 mol) and NaN3 (5.67 g, 0.0872 mol) were added, followed by DMF (200 mL). Subsequently, the flask wassealed with a glass stopper and submerged in an oil bath at 130 C. Thereaction mixture was stirred vigorously for 20 h and the flask was allowed to cool down to ambient temperature. Then, distilled water (150 mL) was added to the reaction mixture, followed by 10% (v/v)aqueous HCl solution, until pH reached the value of 1-2. The product and unreacted 2-iodobenzonitrile precipitated, and was filtered, and washed with water several times. Then, 0.1 N NaOH (500 mL) was added to the precipitate to get a suspension. This suspension wasfilteredto remove the unreacted 2-iodobenzonitrile and the filtrate was collected. Subsequently, 10% (v/v) aqueous HCl solution was added to the filtrate until pH reached the value of 1-2 and the product precipitated. The precipitate was filtered, and washed with water several times, and thenwith diethyl ether. The obtained product was dried under vacuum at 40 C for 24 h and theyield was determined (8.9 g, 75%). 1H NMR (400 MHz, (CD3)2SO): delta 8.10 (d, J = 7.9 Hz, 1H), 7.60 (d, J = 4.1 Hz, 2H), 7.42 – 7.30 (m, 1H).13C{1H} NMR (101 MHz, (CD3)2SO): delta 156.97, 140.26, 132.87, 131.73, 131.01, 128.94, 98.11.
The chemical industry reduces the impact on the environment during synthesis 2-Iodobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Vaish, Avichal; Sayala, Kapil Dev; Tsarevsky, Nicolay V.; Tetrahedron Letters; vol. 60; 35; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com