Related Products of 34270-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Disulfide 18 (82 mg, 0.105 mmol) was treated with NaBH4 (15 mg, 0.39 mmol) in dry DMF (1 mL) for 10 min before a solution of 35 (34 mg, 0.104 mmol) in dry DMF (1 mL) was added. The reaction mixture was stirred at room temperature for 1 h and then diluted with mildly acidic H2O. The aqueous phase was extracted four times with CH2Cl2 before the combined organic phases were concentrated in vacuo. The residue was dissolved in EtOAc and washed five times with H2O. The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (EtOAc/CH2Cl2 1:2) to afford 6 as white solid (24 mg, 27%): Rf: 0.24 (EtOAc/CH2Cl2 1:2); 1H NMR (400 MHz, CDCl3): deltaH 5.87 (s, 1H, H22), 4.98 (dd, 1H, J17,21a 1.6 Hz, Jgem 18.0 Hz, H21a), 4.80 (dd, 1H, J17,21b 1.6 Hz, Jgem 18.0 Hz, H21b), 3.60 (t, 2H, J24,25 7.0 Hz, H25), 3.25 (br s, 1H, H3), 2.77 (m, 1H, H17), 2.67 (t, 2H, J24,25 7.0 Hz, H24), 2.12 (m, 2H), 1.90-1.17 (m, 19H), 0.94 (s, 3H, CH3), 0.86 (s, 3H, CH3); 13C NMR (100 MHz, CDCl3): deltaC 174.7 (C20, C23), 117.8 (C22), 85.7 (C14), 73.6 (C21), 70.9 (C25), 51.0, 49.7 (C13, C17), 44.0, 42.0, 40.1, 37.2, 36.1, 35.7, 33.3, 31.8, 31.3, 30.9, 27.0, 26.9, 26.2, 23.8, 21.7, 21.2, 15.9; HRMS (ES): Calcd for C50H74O7S2Na 873.4773, found 873.4814.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(2-iodoethoxy)ethane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jensen, Marie; Schmidt, Steffen; Fedosova, Natalya U.; Mollenhauer, Jan; Jensen, Henrik H.; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2407 – 2417;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com