Application of 573764-31-5,Some common heterocyclic compound, 573764-31-5, name is 4-Chloro-3-iodoaniline, molecular formula is C6H5ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a microwave reaction vial with a magnetic stir bar, 4-chloro-3-iodoaniline (3) (1 eq, 0.4 mmol) was added, followed by 0.2 M HCl in D2O (1 eq, 2 mL). The vial was capped and sealed and heated in the microwave synthesis apparatus for 30 mins at a temperature of 180°C . The reaction mixture was cooled down and was quenched by additon of 2 mL 3 M NaOH, 1 mL brine and 2 mL Et2O, separating the organic phase and washing with brine.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-3-iodoaniline, its application will become more common.
Reference:
Article; Wang, Fangying; Jiang, Hongxia; Deng, Yufang; Yu, Jiang; Zhan, Miao; Zhao, Lifeng; Chen, Yuanwei; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2399 – 2402;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com