Adding a certain compound to certain chemical reactions, such as: 624-76-0, name is 2-Iodoethanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-76-0, Safety of 2-Iodoethanol
Acetone (4.0 mL) and sat. NaHCO3 aq. (20 mL) were added to a solution of compound 516 (300 mg, 0.640 mmol) in CH2Cl2 (6.0 mL). Then, a solution of Oxone (787 mg, 1.28 mmol) in H2O (10 mL) was dropwise added to this solution at 0 C. The reaction mixture was stirred at room temperature for 3 h. The resulting solution was extracted with CH2Cl2. The combined organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue (310 mg) was dissolved in anhydrous CH2Cl2 (10 mL) under Ar atmosphere, then 2-iodoethanol (0.50 mL, 6.40 mmol) and ZnCl2 (1 M in THF, 0.64 mL, 0.64 mmol) was added to this solution at -78 C. The reaction mixture was stirred at 0 C for 1 h. After being quenched with sat. NaHCO3 aq. at 0 C, the mixture was filtered through a pad of Celite. The filtrate was diluted with EtOAc. The solution was washed with water and brine, dried over Na2SO4, and concentrated in vacuo. The residue (488 mg) was purified by column chromatography (silica gel 10 g, n-hexane: EtOAc = 5:1 to 2:1) to give a diastereomixture of 6 as a white powder (353 mg, 84%, 2 steps from 5).
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Reference:
Article; Osawa, Takashi; Dohi, Masakazu; Hitomi, Yuka; Ito, Yuta; Obika, Satoshi; Hari, Yoshiyuki; Heterocycles; vol. 95; 1; (2017); p. 342 – 352;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com