Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21740-00-1, name is 5-Bromo-2-iodobenzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-2-iodobenzoic acid
General procedure: The reaction of 2-iodobenzoic acid derivatives 1 and carbodiimides derivatives 2 is representative: A round bottom flask was added with 2-iodobenzoic acid derivatives 1 (0.50 mmol), carbodiimides derivatives 2 (1.0 mmol), Cu2O (0.25 mmol), in DMSO (2.5 mL). The reaction mixture was allowed to stir at 90 C for 18 hours. After completion of reaction, the reaction mixture was cooled to room temperature, quenched with 1M HCl, extracted with EtOAc, and DMSO was moved by distilled water. The combined organic layers were washed with brine and dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography to provide quinazolinediones derivatives 3.
The synthetic route of 21740-00-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Duangjan, Chanikan; Rukachaisirikul, Vatcharin; Saithong, Saowanit; Kaeobamrung, Juthanat; Tetrahedron Letters; vol. 59; 39; (2018); p. 3537 – 3540;,
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