Adding a certain compound to certain chemical reactions, such as: 6940-76-7, name is 1-Chloro-3-iodopropane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-76-7, HPLC of Formula: C3H6ClI
A reaction flask or vial was charged 4H-benzo[1,4]ox- azin-3-one (1.0 equiv) dissolved in DMF (0.1 g/ml), Cs2CO3(1.5 equiv) and 1 -chloro-3-iodopropane (1.1 equiv). The reaction was stirred in rt for 60-70 h and evaporated to dryness. The reaction was redisolved in H20 and extractedwith EtOAc 3×1 50 ml. The combined organic phases weredried over Na2SO4 and concentrated to a crude that was useddirectly or purified by column chromatography (heptanes/ EtOAc).5,7-Difluoro-4H-benzo[ 1 ,4]oxazin-3-one (0.24 g, 1.3 mmol), Cs2CO3 (1.08 g, 3.3 mmol), and 1-chloro-3-iodo- propane (0.296 g, 1.45 mmol) were mixed according to GP2.Purified by column chromatography (Si02 heptanes/ EtOAc, gradient 0 to 30% EtOAc) to give the title compound (0.17 g, 49%). R1=0.66 (heptanes/EtOAc 1:1); ?H NMR (CDC13) oe 6.67-6.58 (m, 2H), 4.55 (s, 2H), 4.16-4.10 (m, 2H), 3.59-3.52 (m, 2H), 2.21-2.10 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-3-iodopropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACADIA PHARMACEUTICALS, INC.; Skjaerbaek, Niels; Koch, Kristian Norup; Friberg, Bo Lennart Mikael; Tolf, Bo-Ragnar; (70 pag.)US9522906; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com