Application of 16932-44-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16932-44-8 name is 2-Iodo-1,3-dimethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
at -30 add isopropyl magnesium chloride (2.0M, 5.0mL, 10.0mmol) in THFTo compound 4 (2.64g, 10.0mmol) in anhydrous THF solution (30mL). The temperature was raised to 15 Thereafter, the mixture was stirred for 1 hour. The reaction solution was cooled to -78 , and phosphorus trichloride (0.69g,5.0mmol) were added thereto. At -78 deg.] C the resulting mixture was stirred for 1 hour. The solvent was removed under reduced pressure,To obtain a compound 5.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Iodo-1,3-dimethoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; Japan Polypropylene Corporation; Tanna, Akirahisashi; Sato, Naomasa; Konishi, Yohei; Oishi, Yasuo; (27 pag.)CN105593235; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com