Synthetic Route of 16932-44-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16932-44-8 as follows.
0.2 mmol of potassium carbonate, 0.005 mmol of tris (dibenzylideneacetone) dipalladium,1,3-bis (diphenylphosphine) propane 0.02mmol, 18-crown-6-ether 0.1mmol,1,3-dimethoxy-2-iodobenzene 0.1 mmol,1-phenyl-1-pentyne 0.25 mmol and1 mL of N, N-dimethylformamide was added to a 15 mL reaction tube, Repeatedly filled with nitrogen 10 times, stirred at room temperature for 15min, added 0.5mmol of water,Then placed in a reaction dish at 100 C for 16h; cooled to room temperature, the reaction solution was diluted with ethyl acetate, washed with water, the organic phase was dried over anhydrous Na2SO4, filtered, concentrated, and purified by thin layer chromatography to obtain 8.9mg of the target product Color oil, 32% yield.
According to the analysis of related databases, 16932-44-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Huaqiao University; Cheng Guolin; Lv Weiwei; (12 pag.)CN110256184; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com