Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Iodo-3-(trifluoromethyl)benzene
General procedure: A flask was charged with i-PrMgCl·LiCl (4.63 mL, 1.0807 M) cooled to-20 C, and then neat iodobenzene (1.020 g, 5 mmol) was added. The reaction mixture was stirred for 30 min, and then, a ZnCl2 solution inTHF (5.5 mL, 1 M) was added. The mixture was stirred for 15 min and allowed to warm to r.t. over 30 min. A flask charged with 3e (242 mg, 1 mmol), Pd(dba)2 (30 mg, 5 mol%),and SPhos (40 mg, 10 mol%) was evacuated and back-filled with argon,and then, THF (1.5 mL) was added, and the reaction mixture wasstirred for 5 min. Next, the organozinc reagent PhZnCl (2.10 mL,0.5226 M) was added, and the mixture was stirred for 30 min. Themixture was quenched with aq NH4Cl (0.5 mL), diluted with Et2O (30mL), and the organic layer was washed with sat. aq NH4Cl (2 × 30 mL)and brine (30 mL). The organic layer was dried (MgSO4) and evaporated,and the residue was purified by column chromatography (eluent:CH2Cl2).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Dubovik, Julia; Bredihhin, Aleksei; Synthesis; vol. 47; 4; (2015); p. 538 – 548;,
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